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SB-399885
CAS No. 402713-80-8
SB-399885( SB399885 )
Catalog No. M14378 CAS No. 402713-80-8
SB-399885 is a potent, selective, brain penetrant 5-HT6 receptor antagonist with pKi of 9.11 and 9.02 for human recombinant and native 5-HT6 receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 145 | In Stock |
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| 5MG | 119 | In Stock |
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| 10MG | 177 | In Stock |
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| 25MG | 292 | In Stock |
|
| 50MG | 384 | In Stock |
|
| 100MG | 542 | In Stock |
|
| 200MG | 728 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSB-399885
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NoteResearch use only, not for human use.
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Brief DescriptionSB-399885 is a potent, selective, brain penetrant 5-HT6 receptor antagonist with pKi of 9.11 and 9.02 for human recombinant and native 5-HT6 receptors.
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DescriptionSB-399885 is a potent, selective, brain penetrant 5-HT6 receptor antagonist with pKi of 9.11 and 9.02 for human recombinant and native 5-HT6 receptors; SB-399885 is a potent competitive antagonist (pA(2)=7.85), displays over 200-fold selectivity over other receptors; significantly increases extracellular acetylcholine levels in rat medial prefrontal cortex, exhibits cognitive enhancing properties in recognition models; also is an inhibitor of HCV entry in liver-derived cell lines as well as primary hepatocytes, modulates localization of the coreceptor tight junction protein claudin-1 (CLDN1) in a 5-HT6-independent manner, induces intracellular accumulation of CLDN1.
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In Vitro——
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In Vivo——
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SynonymsSB399885
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number402713-80-8
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Formula Weight446.343
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Molecular FormulaC18H21Cl2N3O4S
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Purity>98% (HPLC)
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Solubility——
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SMILESCOC1=C(C=C(C=C1)S(=O)(=O)NC2=CC(=CC(=C2OC)Cl)Cl)N3CCNCC3.Cl
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Chemical NameN-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Weso?owska A, et al. Eur J Pharmacol. 2008 Mar 17;582(1-3):88-93.
2. Riva L, et al. J Virol. 2018 Apr 27;92(10). pii: e01982-17.
3. Hirst WD, et al. Eur J Pharmacol. 2006 Dec 28;553(1-3):109-19.
4. Weso?owska A, et al. Neuropharmacology. 2007 Apr;52(5):1274-83.
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