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Nitroxoline

CAS No. 4008-48-4

Nitroxoline( Nitroxoline, 5-nitrox, 5-NOK, Cysto-saar plus, Nibiol )

Catalog No. M14371 CAS No. 4008-48-4

Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Nitroxoline
  • Note
    Research use only, not for human use.
  • Brief Description
    Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections.
  • Description
    Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases.
  • In Vitro
    Cell Viability Assay Cell Line:H446, H1882, H1417, and H1688 cells Concentration:2.5 μM, 5 μM, 10 μM, 20 μM Incubation Time:24 hours Result:Effectively inhibit cell survival of small-cell lung cancer (SCLC) cells.Western Blot Analysis Cell Line:H446, H1882, H1417 cells Concentration:5 μM, 10 μM, 20 μM Incubation Time:24 hours Result:Suppressed antiapoptotic proteins (such as Bcl-2 and MCL1) and upregulated proapoptotic protein Bim.
  • In Vivo
    Animal Model:C3H/He mice bladder injected with MBT-2 cells Dosage:15 mg/kg or 60mg/kg Administration:Orally gavage; five times a week on days 1, 2, 4, 5, 7, 8, 10, and 11.Result:Resulted in significant inhibition of tumor growth.
  • Synonyms
    Nitroxoline, 5-nitrox, 5-NOK, Cysto-saar plus, Nibiol
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Fe2+/Zn2+ ions
  • Research Area
    Infection
  • Indication
    ——

Chemical Information

  • CAS Number
    4008-48-4
  • Formula Weight
    190.16
  • Molecular Formula
    C9H6N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    Water: 2.73 g/L
  • SMILES
    OC1=C2C(C=CC=N2)=C([N+]([O-])=O)C=C1
  • Chemical Name
    5-nitroquinolin-8-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chang WL, et al. Oncotarget. 2015 Nov 24;6(37):39806-20.
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