Methacycline hydrochloride

Research use only, not for human use.

Methacycline hydrochloride is a tetracycline antibiotic, and also an inhibitor of epithelial–mesenchymal transition (EMT) with IC50 of roughly 5 μM, used to treat various infections.

Methacycline hydrochloride is a tetracycline antibiotic, and also an inhibitor of epithelial–mesenchymal transition (EMT) with IC50 of roughly 5 μM, used to treat various infections.(In Vitro):Methacycline hydrochloride is an inhibitor of A549 EMT with an IC50 of roughly 5 μM.In vitro, Methacycline hydrochloride (10, 20 μM; for 48 hours) inhibits TGF-β1-induced α-smooth muscle actin, Snail1, and collagen I of primary alveolar epithelial cells. Methacycline hydrochloride inhibits TGF-β1–induced non-Smad pathways, including c-Jun N-terminal kinase, p38, and Akt activation, but not Smad or β-catenin transcriptional activity. Methacycline has no effect on baseline c-Jun N-terminal kinase, p38, or Akt activities or lung fibroblast responses to TGF-β1. (In Vivo):In vivo, Methacycline hydrochloride (100 mg/kg/day; ip; beginning 10 days after intratracheal Bleomycin) improves survival at Day 17. Bleomycin-induced canonical EMT markers, Snail1, Twist1, collagen I, as well as fibronectin protein and mRNA, ARE attenuated by Methacycline hydrochloride (Day 17).

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6-methylene Oxytetracycline | Rondomycin

Microbiology/Virology

ribosome

16S ribosome| 30S ribosome

Infection

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3963-95-9

478.88

C22H23ClN2O8

>98% (HPLC)

Water: 5 mg/mL (10.44 mM); DMSO: 3 mg/mL (6.26 mM)

O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])[C@@H](O)[C@]3([H])C(C4=C(C(C3=C(O)[C@@]21O)=O)C(O)=CC=C4)=C)N.[H]Cl

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, monohydrochloride, (4S,4aR,5S,5aR,12aS)-

(-20℃)

With Ice Pack

≥ 2 years