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UC-112
CAS No. 383392-66-3
UC-112( UC112 )
Catalog No. M14330 CAS No. 383392-66-3
UC-112 is a novel IAP inhibitor that potently inhibits human melanoma (A375 and M14) and human prostate (PC-3 and DU145) cancer cell lines with IC50 of 0.7-3.4 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 71 | In Stock |
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| 2MG | 37 | In Stock |
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| 5MG | 64 | In Stock |
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| 10MG | 101 | In Stock |
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| 25MG | 214 | In Stock |
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| 50MG | 322 | In Stock |
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| 100MG | 460 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameUC-112
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NoteResearch use only, not for human use.
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Brief DescriptionUC-112 is a novel IAP inhibitor that potently inhibits human melanoma (A375 and M14) and human prostate (PC-3 and DU145) cancer cell lines with IC50 of 0.7-3.4 uM.
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DescriptionUC-112 is a novel IAP inhibitor that potently inhibits human melanoma (A375 and M14) and human prostate (PC-3 and DU145) cancer cell lines with IC50 of 0.7-3.4 uM; also potently inhibits the growth of P-gp-overexpressed multidrug-resistant cancer cells, strongly activates caspase-3/7 and caspase-9 activities, and selectively downregulates survivin level at 1 uM; strongly inhibits tumor growth and reduces both X chromosome-linked IAP and survivin levels in an A375 human melanoma xenograft model in vivo.
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In Vitro——
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In Vivo——
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SynonymsUC112
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PathwayApoptosis
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TargetIAP
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RecptorIAP
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number383392-66-3
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Formula Weight348.4382
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Molecular FormulaC22H24N2O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESOC1=C2N=CC=CC2=C(COCC3=CC=CC=C3)C=C1CN4CCCC4
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Chemical Name8-Quinolinol, 5-[(phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang J, et al. J Pharmacol Exp Ther. 2014 May;349(2):319-29.
2. Xiao M, et al. PLoS One. 2015 Jun 12;10(6):e0129807.
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