Amikacin( Antibiotic BB-K 8 | BAY 41-6551 | BB-K 8 | Lukadin | Potentox )

Catalog No. M14293 CAS No. 37517-28-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Amikacin
Note

Research use only, not for human use.
Brief Description

A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.
Description

A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.(In Vitro):Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by Nocardia asteroides, Mycobacterium avium-intracellulare, and certain species of "rapid-growing" mycobacteria (that is, M. chelonae and M. fortuitumi).Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD50 value of 453 μM.(In Vivo):Amikacin (320 mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo.
In Vitro

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In Vivo

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Synonyms

Antibiotic BB-K 8 | BAY 41-6551 | BB-K 8 | Lukadin | Potentox
Pathway

Microbiology/Virology
Target

ribosome
Recptor

30S ribosome
Research Area

——
Indication

——

CAS Number

37517-28-5
Formula Weight

585.6
Molecular Formula

C22H43N5O13
Purity

>98% (HPLC)
Solubility

Soluble in Water
SMILES

C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1NC(=O)[C@H](CCN)O)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CN)O)O)O)N
Chemical Name

——

1.Tolmasky ME. Front Biosci. 2000 Jan 1;5:D20-9.

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