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SB-612111 hydrochloride
CAS No. 371980-94-8
SB-612111 hydrochloride( SB 612111 | SB612111 )
Catalog No. M14285 CAS No. 371980-94-8
A potent, selective opiate receptor-like orphan receptor (ORL-1, NOP) antagonist with Ki of 0.33 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1503 | Get Quote |
|
| 50MG | 3042 | Get Quote |
|
| 100MG | 4140 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameSB-612111 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective opiate receptor-like orphan receptor (ORL-1, NOP) antagonist with Ki of 0.33 nM.
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DescriptionA potent, selective opiate receptor-like orphan receptor (ORL-1, NOP) antagonist with Ki of 0.33 nM; displays good selectivity versus mu-(174-fold), delta-(6391-fold), and kappa (486-fold)-opioid receptors; antagonizes the antimorphine action of nociceptin (ED50= 0.69 mg/kg) with no measurable antinociceptive effects in vivo; antagonizes nociceptin-induced thermal hyperalgesia (ED50=0.62 mg/kg i.v.) in rat carrageenan inflammatory pain model.
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In Vitro——
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In Vivorel-SB-612111 hydrochloride (intravenous?injection; 0.6-10 nmol/mouse)antagonize nociceptin-induced thermal hyperalgesia in a dose-dependent manner with an ED50 of 0.62 mg/kg.rel-SB-612111 hydrochloride (intravenous?injection; 0.1-5 mg/kg) causes a significant inhibition of the carrageenan-induced reduction in paw withdrawal latencies in rat, however, untreated paw are uneffected. Animal Model:Male rats Dosage:0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 5 mg/kg Administration:Intravenous?injection; single dose Result:Had antihyperalgesic effects on carrageenan-induced rat paw.
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SynonymsSB 612111 | SB612111
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PathwayEndocrinology/Hormones
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TargetOpioid Receptor
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RecptorOpioid Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number371980-94-8
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Formula Weight454.86
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Molecular FormulaC24H29Cl2NO.HCl
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=C2CCC(CC(C2=CC=C1)O)CN3CCC(CC3)C4=C(C=CC=C4Cl)Cl.Cl
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Chemical Name7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Liao YY, et al. Eur J Pharmacol. 2011 Apr 25;657(1-3):84-8.
2. Spagnolo B, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):961-7.
3. Rizzi A, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):968-74.
4. Zaratin PF, et al. J Pharmacol Exp Ther. 2004 Feb;308(2):454-61.
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