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YM-201636
CAS No. 371942-69-7
YM-201636( YM 201636 | YM201636 )
Catalog No. M14284 CAS No. 371942-69-7
YM-201636 is a potent, selective PIKfyve inhibitor with IC50 of 33 nM, does not inhibits type Iiγ/Iα PtdInsP kinases even at 10 uM (p110α IC50=3.3 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 2MG | 55 | In Stock |
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| 5MG | 92 | In Stock |
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| 10MG | 174 | In Stock |
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| 25MG | 359 | In Stock |
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| 50MG | 551 | In Stock |
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| 100MG | 786 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 1609 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameYM-201636
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NoteResearch use only, not for human use.
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Brief DescriptionYM-201636 is a potent, selective PIKfyve inhibitor with IC50 of 33 nM, does not inhibits type Iiγ/Iα PtdInsP kinases even at 10 uM (p110α IC50=3.3 uM).
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DescriptionYM-201636 is a potent, selective PIKfyve inhibitor with IC50 of 33 nM, does not inhibits type Iiγ/Iα PtdInsP kinases even at 10 uM (p110α IC50=3.3 uM); shows insensitivity against yeast orthologue of PIKfyve, Fab1; significantly decreases the production of PtdIns(3,5)P2 by 80% in serum-starved NIH3T3 cells with no effect on serum-stimulated PKB Ser 473 phosphorylation at 0.8 uM; inhibits basal and insulin-activated 2-deoxyglucose uptake withIC50 of 54 nM; significantly reduces retroviruses budding from cells; blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells.
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In Vitro——
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In Vivo——
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SynonymsYM 201636 | YM201636
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PathwayPI3K/Akt/mTOR signaling
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TargetPIKfyve
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Recptorp110α|PIKfyve
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number371942-69-7
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Formula Weight467.4793
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Molecular FormulaC25H21N7O3
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 47 mg/mL
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SMILESO=C(C1=CC=C(N)N=C1)NC2=CC=CC(C3=NC(N4CCOCC4)=C(OC5=NC=CC=C56)C6=N3)=C2
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Chemical Name3-Pyridinecarboxamide, 6-amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jefferies HB, et al. EMBO Rep. 2008 Feb;9(2):164-70.
2. Osborne SL, et al. J Biol Chem. 2008 Feb 1;283(5):2804-13.
3. Ikonomov OC, et al. Biochem Biophys Res Commun. 2009 May 8;382(3):566-70.
4. Kerr MC, et al. EMBO J. 2010 Apr 21;29(8):1331-47.
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