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AY-9944
CAS No. 366-93-8
AY-9944( AY9944 )
Catalog No. M14261 CAS No. 366-93-8
AY-9944 is a cholesterol biosynthesis inhibitor that targets the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 48 | In Stock |
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| 5MG | 77 | In Stock |
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| 10MG | 132 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAY-9944
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NoteResearch use only, not for human use.
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Brief DescriptionAY-9944 is a cholesterol biosynthesis inhibitor that targets the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM).
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DescriptionAY-9944 is a cholesterol biosynthesis inhibitor that targets the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM), attenuates of Smoothened-dependent and -independent Hh signaling; has been used to recapitulate phenotypes of Smith-Lemli-Opitz syndrome in animal model.
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In VitroCell Viability Assay Cell Line:Human foreskin keratinocytes Concentration:1 μg/mL Incubation Time:15 hours Result:Inhibited the synthesis of cholesterol and desmosterol, but increased 7-dehydrocholesterol and zymosterol synthesis.
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In VivoAnimal Model:Long–Evans hooded rats.Dosage:7.5 mg/kg Administration:Subcutaneous injection; 7.5 mg/kg every 6 days once; from postnatal day 2 to postnatal day 20 Result:Reduced brain cholesterol and increased 7-dehydrocholesterol in all brain regions of rats till the treatment stopped for 400 days and showed a more severe effect on the change of sterols in plasma and liver of female rats.
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SynonymsAY9944
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PathwayGPCR/G Protein
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TargetHedgehog (Hh)
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RecptorHedgehog (Hh)
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Research Area——
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Indication——
Chemical Information
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CAS Number366-93-8
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Formula Weight464.3
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Molecular FormulaC22H28Cl2N2 ? 2HCl
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5 mg/mL (10.77 mM)
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SMILESClC1=CC=CC=C1CNC[C@H]2CC[C@H](CNCC3=CC=CC=C3Cl)CC2.Cl.Cl
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Chemical Nametrans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Horlick L. J Lipid Res. 1966 Jan;7(1):116-21.
2. Lauth M, et al. Mol Pharmacol. 2010 Sep;78(3):486-96.
3. Xu L, et al. J Lipid Res. 2011 Oct;52(10):1810-20.
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