PJ-68( PJ68 )

Catalog No. M14202 CAS No. 352544-59-3

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Datasheet

HNMR

HPLC

MSDS

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Product Name

PJ-68
Note

Research use only, not for human use.
Brief Description

PJ-68 is a potent, selective inhibitor of arginine methyltransferase PRMT5 with IC50 of 517 nM.
Description

PJ-68 is a potent, selective inhibitor of arginine methyltransferase PRMT5 with IC50 of 517 nM, shows no inhibitory activity against type I PRMT family members ( (PRMT1, 3, 4, 6, and 8); markedly decreases BCR-ABL mRNA levels in both CD34+CD38-cells and CD34+CD38+ cells, reduces survival and self-renewal capacity of CML CD34+ cells, increases p15INK4B and p27KIP1 but not p16INK4A and p57KIP2 expression; reduces growth of CML LSCs and prolongs survival of CML mice.
In Vitro

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In Vivo

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Synonyms

PJ68
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

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Indication

——

CAS Number

352544-59-3
Formula Weight

354.497
Molecular Formula

C25H26N2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

N-((9-ethyl-9H-carbazol-3-yl)methyl)-1,2,3,4-tetrahydronaphthalen-1-amine

1. Jin Y, et al. J Clin Invest. 2016 Oct 3;126(10):3961-3980. 2. Kaushik S, et al. Leukemia. 2018 Feb;32(2):499-509.

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