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Tonapofylline
CAS No. 340021-17-2
Tonapofylline( BG 9928 | BG9928 )
Catalog No. M14153 CAS No. 340021-17-2
A potent, selective and orally bioavailable adenosine A1 (A1A) receptor antagonist with Ki of 7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 92 | In Stock |
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| 5MG | 84 | In Stock |
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| 10MG | 135 | In Stock |
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| 25MG | 271 | In Stock |
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| 50MG | 385 | In Stock |
|
| 100MG | 548 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTonapofylline
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective and orally bioavailable adenosine A1 (A1A) receptor antagonist with Ki of 7 nM.
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DescriptionA potent, selective and orally bioavailable adenosine A1 (A1A) receptor antagonist with Ki of 7 nM; displays 915-foldselectivity over A2A receptor, 12-fold over A2B receptor; increases sodium excretion and cause natriuresis without causing kaliuresis or reducing renal function.Heart Failure Phase 2 Discontinued.
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In Vitro——
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In VivoAnimal Model:Female viral antigen-free Sprague-Dawley rats Dosage:1 mg/kg Administration:Oral administration; twice a day, days 0-6 Result:Produced sustained reductions in post-NSC 119875 serum creatinine and blood urea nitrogen levels, improved body weight recovery and significant attenuation of NSC 119875-induced (5.5 mg/kg) kidney pathology scores.
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SynonymsBG 9928 | BG9928
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PathwayApoptosis
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TargetAdenosine Receptor
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RecptorAdenosine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number340021-17-2
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Formula Weight416.522
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Molecular FormulaC22H32N4O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (240.09 mM)
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SMILESO=C(O)CCC1(CC2)CCC2(C(N3)=NC(N(CCC)C(N4CCC)=O)=C3C4=O)CC1
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Chemical Name1,3-dipropyl-8-[1-(4-propionate)-bicyclo-[2,2,2]octyl]xanthine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Auchampach JA, et al. J Pharmacol Exp Ther. 2004 Mar;308(3):846-56.
2. Kiesman WF, et al. J Med Chem. 2006 Nov 30;49(24):7119-31.
3. Greenberg B, et al. J Am Coll Cardiol. 2007 Aug 14;50(7):600-6.
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