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NBD-557
CAS No. 333352-59-3
NBD-557( NBD 557 | NBD557 )
Catalog No. M14122 CAS No. 333352-59-3
A potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction; inhibits the fusion between HIV-1NL4-3-luc pseudotyped virus expressing HIV-1HXB2 (X4-tropic) envelope and U87-T4-CXCR4 cells with IC50 of 9.7 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 110 | In Stock |
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| 5MG | 177 | In Stock |
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| 10MG | 327 | In Stock |
|
| 25MG | 554 | In Stock |
|
| 50MG | 789 | In Stock |
|
| 100MG | 1062 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNBD-557
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NoteResearch use only, not for human use.
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Brief DescriptionA potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction; inhibits the fusion between HIV-1NL4-3-luc pseudotyped virus expressing HIV-1HXB2 (X4-tropic) envelope and U87-T4-CXCR4 cells with IC50 of 9.7 uM.
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DescriptionA potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction; inhibits the fusion between HIV-1NL4-3-luc pseudotyped virus expressing HIV-1HXB2 (X4-tropic) envelope and U87-T4-CXCR4 cells with IC50 of 9.7 uM; inhibits the laboratory-adapted HIV-1 strains IIIB, MN, and V32 with IC50 of 5-16 uM.HIV Infection Preclinical.
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In Vitro——
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In Vivo——
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SynonymsNBD 557 | NBD557
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV
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Research AreaInfection
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IndicationHIV Infection
Chemical Information
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CAS Number333352-59-3
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Formula Weight382.2953
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Molecular FormulaC17H24BrN3O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NC1=CC=C(Br)C=C1)C(NC2CC(C)(C)NC(C)(C)C2)=O
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Chemical NameEthanediamide, N-(4-bromophenyl)-N'-(2,2,6,6-tetramethyl-4-piperidinyl)- (9CI)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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MK-8591
MK-8591 (Islatravir, MK8591, EFdA) is a nucleoside analog that exhibits remarkable potency against wild-type and drug-resistant HIVs.
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Apelin-36 (rat, mous...
Endogenous APJ receptor agonist that is secreted by adipocytes. Binds with high affinity to APJ receptors (IC50 = 5.4 nM) and potently inhibits cAMP production in vitro (EC50 = 0.52 nM). Involved in regulation of cardiovascular function, fluid homeostasis and feeding. Blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ.
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Peptide T
Peptide T is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a synthetic octapeptide whose possible mechanism of action is the competitive inhibition of gp120 to the CD4 receptor as well as binding to vasointestinal peptide receptors and inhibiting cytokine action.
