Cart
sales@molnova.com
NBD-557
CAS No. 333352-59-3
NBD-557( NBD 557 | NBD557 )
Catalog No. M14122 CAS No. 333352-59-3
A potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction; inhibits the fusion between HIV-1NL4-3-luc pseudotyped virus expressing HIV-1HXB2 (X4-tropic) envelope and U87-T4-CXCR4 cells with IC50 of 9.7 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 71 | In Stock |
|
| 5MG | 65 | In Stock |
|
| 10MG | 105 | In Stock |
|
| 25MG | 211 | In Stock |
|
| 50MG | 300 | In Stock |
|
| 100MG | 425 | In Stock |
|
| 200MG | 578 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameNBD-557
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction; inhibits the fusion between HIV-1NL4-3-luc pseudotyped virus expressing HIV-1HXB2 (X4-tropic) envelope and U87-T4-CXCR4 cells with IC50 of 9.7 uM.
-
DescriptionA potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction; inhibits the fusion between HIV-1NL4-3-luc pseudotyped virus expressing HIV-1HXB2 (X4-tropic) envelope and U87-T4-CXCR4 cells with IC50 of 9.7 uM; inhibits the laboratory-adapted HIV-1 strains IIIB, MN, and V32 with IC50 of 5-16 uM.HIV Infection Preclinical.
-
In Vitro——
-
In Vivo——
-
SynonymsNBD 557 | NBD557
-
PathwayMicrobiology/Virology
-
TargetHIV
-
RecptorHIV
-
Research AreaInfection
-
IndicationHIV Infection
Chemical Information
-
CAS Number333352-59-3
-
Formula Weight382.2953
-
Molecular FormulaC17H24BrN3O2
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESO=C(NC1=CC=C(Br)C=C1)C(NC2CC(C)(C)NC(C)(C)C2)=O
-
Chemical NameEthanediamide, N-(4-bromophenyl)-N'-(2,2,6,6-tetramethyl-4-piperidinyl)- (9CI)
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Zhao Q, et al. Virology. 2005 Sep 1;339(2):213-25.
2. Sch?n A, et al. Biochemistry. 2006 Sep 12;45(36):10973-80.
3. Curreli F, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5478-91.
molnova catalog
related products
-
CHLOROQUINE
Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis.
-
HIV p17 Gag 77-85
HIV p17 Gag (77-85) is an attractive target for molecular intervention, because it is involved in the viral replication cycle at both the pre- and postintegration levels. In the present experiments, we targeted p17 by intracellularly expressing a cDNA encoding an Ab to p17.
-
PF-3450074
PF-3450074 (PF74) is a small molecule HIV capsid protein, destabilized the viral capsid in vitro; acts at an early stage of HIV-1 infection and inhibits reverse transcription in target cells.
