ABMA

Research use only, not for human use.

ABMA is a novel broad-spectrum inhibitor of intracellular toxins and pathogens, efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite.

ABMA is a novel broad-spectrum inhibitor of intracellular toxins and pathogens, efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite; protects mice from nasal instillation of an LD90 of ricin; provokes Rab7-positive late endosomal compartment accumulation in mammalian cells without affecting other organelles.

ABMA protects cells against four bacterial toxins (Corynebacterium diphtheriae (DT; EC50 of 62.9 μM), Bacillus anthracis (LT), Clostridium difficile toxin B (TcdB; EC50 of 73.3μM), Clostridium sordellii lethal toxin (TcsL; EC50 of 86.7 μM)), three viruses (Ebola (EC50 of 3.3μM), rabies (EC50 of 19.4μM), dengue-4 virus ( EC50 of 8.2?μM)), two species of Chlamydiales intracellular bacteria (Simkania negevensis and Chlamydia trachomatis), and the parasite Leishmania infantum (EC50 of 7.1μM) at micromolar level.In A549 cells, ABMA treatment induces a decrease in ricin cytotoxicity with an EC50 of 3.8?μM, and a protection factor (R) at 30?μM ranging from 5 to 10. ABMA retained almost 100% of its biological activity against ricin-induced cytotoxicity up to six days.

Animal Model:Pathogen-free female BALB/c mice (6 week-old) with ricin Dosage:2 mg/kg, 20 mg/kg, 200 mg/kg Administration:Intraperitoneal injection Result:A statistically significant protection according to survival curves was observed with a single ip dose of 2?mg/kg. The 20?mg/kg dose fully protected animals through to day 21. The 200?mg/kg dose resulted in 80% of protection of mice against ricin challenge with a single animal succumbing on day 15.

——

GPCR/G Protein

Antibacterial

Antibacterial

——

——

332108-65-3

350.3

C18H24BrNO

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (356.85 mM)

——

1-adamantyl (5-bromo-2-methoxybenzyl) amine

(-20℃)

With Ice Pack

≥ 2 years