Lethal toxin inhibitor DN1

Research use only, not for human use.

Lethal toxin inhibitor DN1 is a small molecule that reduces the cytotoxicity of anthrax lethal toxin (LT) an inhibitor of LT-induced pyroptosis.

Lethal toxin inhibitor DN1 is a small molecule that reduces the cytotoxicity of anthrax lethal toxin (LT) an inhibitor of LT-induced pyroptosis, acts as an antagonist of GPCR receptors type-1 angiotensin II receptor (AGTR1) and apelin receptor (APLNR) with IC50 of 1.958 and 2.280 uM, respectively; protected cells irrespectively of LT concentration and reduced the pathogenicity of an additional bacterial exotoxin and several viruses, does not prevent LT internalization and catalytic activity or caspase-1 activation, also reduced the susceptibility of Drosophila melanogaster to toxin-associated bacterial infections.

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GPCR/G Protein

Antibacterial

Antibacterial

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325990-63-4

257.268

C14H12FN3O

>98% (HPLC)

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CC(=NNC(=O)C1=CC=C(C=C1)F)C2=CC=CC=N2

4-fluoro- N'-[1-(2-pyridinyl)ethylidene]benzohydrazide

(-20℃)

With Ice Pack

≥ 2 years