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Beta-d-N4-hydroxycytidine

CAS No. 3258-02-4

Beta-d-N4-hydroxycytidine( NHC )

Catalog No. M14056 CAS No. 3258-02-4

Beta-d-N4-hydroxycytidine (NHC) is a nucleoside analogue that has antipestivirus and antihepacivirus activities.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Beta-d-N4-hydroxycytidine
  • Note
    Research use only, not for human use.
  • Brief Description
    Beta-d-N4-hydroxycytidine (NHC) is a nucleoside analogue that has antipestivirus and antihepacivirus activities.
  • Description
    Beta-d-N4-hydroxycytidine (NHC) is a nucleoside analogue that has antipestivirus and antihepacivirus activities; inhibits the production of cytopathic BVDV RNA with EC90 of 5.4 uM, also has an EC50 of 5 uM for replicon RNA reduction in Huh7 cells; also is a novel inhibitor of CHIKV (Chikungunya virus), inhibits venezuelan equine encephalitis virus (VEEV) with EC50 of <1 uM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NHC
  • Pathway
    Microbiology/Virology
  • Target
    HCV
  • Recptor
    HCV
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    3258-02-4
  • Formula Weight
    259.218
  • Molecular Formula
    C9H13N3O6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (385.77 mM)
  • SMILES
    C1=CN(C(=O)N=C1NO)C2C(C(C(O2)CO)O)O
  • Chemical Name
    1-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyamino)pyrimidin-2(1H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Stuyver LJ, et al. Antimicrob Agents Chemother. 2003 Jan;47(1):244-54. 2. Barnard DL, et al. Antivir Chem Chemother. 2004 Jan;15(1):15-22. 3. Urakova N, et al. J Virol. 2017 Nov 22. pii: JVI.01965-17. 4. Ehteshami M, et al. Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02395-16.
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