BRD4354( BRD 4354 )

Catalog No. M14024 CAS No. 315698-07-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

BRD4354
Note

Research use only, not for human use.
Brief Description

BRD4354 is a moderately potent, selective, reversible inhibitor of HDAC5 and HDAC9 with IC50 of 0.85 uM and 1.88 uM.
Description

BRD4354 is a moderately potent, selective, reversible inhibitor of HDAC5 and HDAC9 with IC50 of 0.85 uM and 1.88 uM; shows weak activity against HDACs 4, 6, 7, and 8 (IC50=3.88-13.8 uM) and no inhibitory effect on other class I HDACs 1, 2, and 3 (IC50 > 40 uM).
In Vitro

BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with BRD4354 having half-maximum inhibitory concentrations (IC50) of 0.85 μM and 1.88 μM, respectively. BRD 4354 also inhibits HDACs 4, 6, 7, and 8 at higher concentrations (3.88-13.8 μM) but demonstrates less of an inhibitory effect on other class I HDACs 1, 2, and 3 (IC50>40 μM) .
In Vivo

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Synonyms

BRD 4354
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC
Research Area

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Indication

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CAS Number

315698-07-8
Formula Weight

382.892
Molecular Formula

C21H23ClN4O
Purity

>98% (HPLC)
Solubility

DMSO : 125 mg/mL326.46 mM;
SMILES

OC1=C2N=CC=CC2=C(Cl)C=C1C(N3CCN(CC)CC3)C4=CC=CN=C4
Chemical Name

5-chloro-7-((4-ethylpiperazin-1-yl)(pyridin-3-yl)methyl)quinolin-8-ol

1. Boskovic ZV, et al. ACS Chem Biol. 2016 Jul 15;11(7):1844-51.

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