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M2I-1
CAS No. 312271-03-7
M2I-1( Mad2 inhibitor 1 )
Catalog No. M13998 CAS No. 312271-03-7
The first small molecule Mad2 inhibitor that targets the binding of Mad2 to Cdc20; equally potent in inhibiting the binding of F-Mbp1 to Mad2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 36 | In Stock |
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| 5MG | 32 | In Stock |
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| 10MG | 50 | In Stock |
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| 25MG | 107 | In Stock |
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| 50MG | 166 | In Stock |
|
| 100MG | 277 | In Stock |
|
| 200MG | 403 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameM2I-1
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NoteResearch use only, not for human use.
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Brief DescriptionThe first small molecule Mad2 inhibitor that targets the binding of Mad2 to Cdc20; equally potent in inhibiting the binding of F-Mbp1 to Mad2.
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DescriptionThe first small molecule Mad2 inhibitor that targets the binding of Mad2 to Cdc20; equally potent in inhibiting the binding of F-Mbp1 to Mad2; disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20, weakens the spindle assembly checkpoint (SAC) response.
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In VitroM2I-1 may not be sufficiently potent to fully inhibit SAC function in cells.M2I-1 weakens the SAC response, indicating that the compound might be active in cells..
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In Vivo——
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SynonymsMad2 inhibitor 1
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PathwayAngiogenesis
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TargetCDK
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RecptorOthers
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number312271-03-7
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Formula Weight404.4832
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Molecular FormulaC19H24N4O4S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 32 mg/mL
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SMILESO=C(/C(C(N1)=O)=C\C2=CC=C(N(CC(C)C)CC(C)C)C([N+]([O-])=O)=C2)NC1=S
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Chemical Name4,6(1H,5H)-Pyrimidinedione, 5-[[4-[bis(2-methylpropyl)amino]-3-nitrophenyl]methylene]dihydro-2-thioxo-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kastl J, et al. ACS Chem Biol. 2015 Jul 17;10(7):1661-6.
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