M2I-1( Mad2 inhibitor 1 )

Catalog No. M13998 CAS No. 312271-03-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

M2I-1
Note

Research use only, not for human use.
Brief Description

The first small molecule Mad2 inhibitor that targets the binding of Mad2 to Cdc20; equally potent in inhibiting the binding of F-Mbp1 to Mad2.
Description

The first small molecule Mad2 inhibitor that targets the binding of Mad2 to Cdc20; equally potent in inhibiting the binding of F-Mbp1 to Mad2; disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20, weakens the spindle assembly checkpoint (SAC) response.
In Vitro

M2I-1 may not be sufficiently potent to fully inhibit SAC function in cells.M2I-1 weakens the SAC response, indicating that the compound might be active in cells..
In Vivo

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Synonyms

Mad2 inhibitor 1
Pathway

Angiogenesis
Target

CDK
Recptor

Others
Research Area

Other Indications
Indication

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CAS Number

312271-03-7
Formula Weight

404.4832
Molecular Formula

C19H24N4O4S
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 32 mg/mL
SMILES

O=C(/C(C(N1)=O)=C\C2=CC=C(N(CC(C)C)CC(C)C)C([N+]([O-])=O)=C2)NC1=S
Chemical Name

4,6(1H,5H)-Pyrimidinedione, 5-[[4-[bis(2-methylpropyl)amino]-3-nitrophenyl]methylene]dihydro-2-thioxo-

1. Kastl J, et al. ACS Chem Biol. 2015 Jul 17;10(7):1661-6.

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