P7C3

Research use only, not for human use.

The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration.

The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, before neuronal cell death occurs, in a rodent model of blast-mediated traumatic brain injury (TBI). This protective quality may be linked to the ability of P7C3 molecules to activate nicotinamide phosphoribosyltransferase, the rate-limiting enzyme in nicotinamide adenine dinucleotide salvage.

Western Blot Analysis Cell Line:BV2 cells Concentration:0.1 μM, 1 μM, 10 μM Incubation Time:2 hours Result:Reduced the protein levels of iNOS, COX-2.

Animal Model:6-8 weeks male C57BL/6 mice (25-30 g)Dosage:20 mg/kg/d Administration:Intraperitoneal injection, twice daily, for 21 days Result:Strikingly decreased the expressions of (a microglia marker) and GFAP (an astrocyte marker) LPS-induced in the substantia nigra pars compacta (SNpc).

P7C3

Others

Other Targets

nicotinamide phosphoribosyltransferase

Neurological Disease

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301353-96-8

474.19

C21H18Br2N2O

>98% (HPLC)

Soluble in DMSO

OC(CNC1=CC=CC=C1)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3

1-(3,6-dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol

(-20℃)

With Ice Pack

≥ 2 years