Indazole( —— )

Catalog No. M13828 CAS No. 271-44-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Indazole
Note

Research use only, not for human use.
Brief Description

Indazole, also called benzpyrazole or isoindazone, is a heterocyclic aromatic organic compound.
Description

Indazole, also called benzpyrazole or isoindazone, is a heterocyclic aromatic organic compound. Indazole derivatives display a broad variety of biological activities.
In Vitro

Indazole compounds possess potential anticancer activity, and indazole-based agents such as, Axitinib (HY-10065), Lonidamine (HY-B0486) and Pazopanib (HY-10208) have already been used for cancer research, demonstrating indazole compounds as useful templates for the development of novel anticancer agents.Indazoles show potent activities against neurological disorders by inhibiting the monoamine oxidase (MAO) and kinase enzymes like Glycogen synthase kinase 3 (GSK3), and leucinerich repeat kinase enzyme 2 (LRRK2). Various natural and synthetic indazole derivatives Nigellicine, Nigellamine, Nigellidine, Zanubrutinib (HY-101474A) and SCH772984 (HY-50846) showes prominent results to cure various gastrointestinal disorders.
In Vivo

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Synonyms

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Pathway

Membrane Transporter/Ion Channel
Target

Sodium Channel
Recptor

Sodium Channel
Research Area

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Indication

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1.Matsumura N, et al. Epilepsy Res. 2013 May;104(3):203-16.

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