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Etamsylate
CAS No. 2624-44-4
Etamsylate( Ethamsylate | E 141 | MD 141 | Aglumin | Altodor | Eselin )
Catalog No. M13801 CAS No. 2624-44-4
Ethamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
|
| 50MG | 27 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameEtamsylate
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NoteResearch use only, not for human use.
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Brief DescriptionEthamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.
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DescriptionEthamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.
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In VitroCell Migration Assay Cell Line:HMEC-1 and HUVECs cells Concentration:0-100 μM Incubation Time:3-8 h Result:Didn’t affect the migration of HMEC-1 cells.Inhibited the migration of HUVECs cells.Thinned the morphology of the closed network and enlarged the closed cells.Western Blot Analysis Cell Line:HUVECs cells Concentration:0-100 μM Incubation Time:48 h Result:Decreased the amount of Akt1 phosphorylated.Decreased pERK2 levels at the highest doses (50-100 μM).
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In VivoAnimal Model:C57BL/6J female mice of spinal cord injury Dosage:100 mg/kg Administration:Oral gavage (p.o.), twice a day, three days Result:Attenuated the MMP-9 expression.Inhibited the degradation of TJ proteins.Reduced the upregulation of IL-1β, IL-6, and TNF-α.Reduced axonal demyelination and decreased cystic cavity formation.Reduced the extent of Fibrotic scar formation.
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SynonymsEthamsylate | E 141 | MD 141 | Aglumin | Altodor | Eselin
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PathwayAutophagy
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TargetThrombin
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RecptorThrombopoiesis
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number2624-44-4
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Formula Weight263.31
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Molecular FormulaC10H17NO5S
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Purity>98% (HPLC)
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SolubilityWater: 53 mg/mL (201.28 mM); DMSO: 53 mg/mL (201.28 mM)
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SMILESO=S(C1=CC(O)=CC=C1O)(O)=O.CCNCC
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Chemical NameBenzenesulfonic acid, 2,5-dihydroxy-, compd. with diethylamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Garay RP, et al. Am J Ther, 2006, 13(3), 236-247.
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