Dantrolene sodium hemiheptahydrate

Research use only, not for human use.

Dantrolene is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells.

Dantrolene is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells, inhibits Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.

RT-PCR Cell Line:Porcine aortic valvular interstitial cells (paVICs) Concentration:60 μM.Incubation Time:At 1 and 3 days Result:Significantly inhibited ACTA2 expression and upregulated RUNX2 expression.

Animal Model:YAC128 transgenic mice (FVBN/NJ background strain) and WT mice Dosage:5 mg/kg Administration:Fed orally twice per week from 2 to 11.5 months of age Result:Resulted in significantly improved performance in the beam-walking and gait-walking assays. Significantly reduced the loss of NeuN-positive striatal neurons and reduced formation of Httexp nuclear aggregates.

Dantrolene sodium hydrate

GPCR/G Protein

Calcium Channel

Others

Other Indications

——

24868-20-0

400.3

C14H17N4NaO8.5

>98% (HPLC)

DMSO: ≥ 33 mg/mL

C1C(=NC(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])[O-].C1C(=NC(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])[O-].O.O.O.O.O.O.O.[Na+].[Na+]

2,4-Imidazolidinedione, 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-, sodium salt, hydrate (2:2:7)

(-20℃)

With Ice Pack

≥ 2 years