Cart
sales@molnova.com
MU1210
CAS No. 2275601-87-9
MU1210( MU-1210 | MU 1210 )
Catalog No. M13620 CAS No. 2275601-87-9
MU1210 (MU-1210) is a potent and highly selective inhibitor of cdc-like kinases (CLKs) with IC50 of 51 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameMU1210
-
NoteResearch use only, not for human use.
-
Brief DescriptionMU1210 (MU-1210) is a potent and highly selective inhibitor of cdc-like kinases (CLKs) with IC50 of 51 nM.
-
DescriptionMU1210 (MU-1210) is a potent and highly selective inhibitor of cdc-like kinases (CLKs) with IC50 of 51 nM (cellular BRET for CLK1); profoundly affected the Mdm4 alternative splicing and showed high activity in cytotoxicity assays using MCF7 breast cancer cells; MU1210 has favorable pharmacokinetics (mouse, 10 mpk, IP: Cmax =1.24 mm, T1/2 = 58 min; no acute toxicity observed), suggesting its potential use in in vivo models; MU1210 is a quality probe for CLK1, CLK2, and CLK4.
-
In Vitro——
-
In Vivo——
-
SynonymsMU-1210 | MU 1210
-
PathwayCell Cycle/DNA Damage
-
TargetCLK
-
RecptorCLK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2275601-87-9
-
Formula Weight352.397
-
Molecular FormulaC22H16N4O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name5-(1-methyl-1H-pyrazol-4-yl)-3-(3-(pyridin-4-yl)phenyl)furo[3,2-b]pyridine
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Němec V, et al. Angew Chem Int Ed Engl. 2019 Jan 21;58(4):1062-1066.
molnova catalog
related products
-
ML197
ML197 is a potent, selective small molecule inhibitor of Cdc2-like kinases (CLK) and DYRK with IC50 of 96/40/206 nM for CLK1/CLK4/Dyrk1A, respectively.
-
CLK2 inhibitor Indaz...
CLK2 inhibitor Indazole1 is a novel potent, selective inhibitor of CLK2 with IC50 of 2.7 nM.
-
Leucettamine B
Leucettamine B is a potent inhibitor of CLK1 (IC50=15 nM), Dyrk1A (IC50=40 nM), and Dyrk2 (IC50=35 nM) and a moderate inhibitor of CLK3 (IC50=4.5 uM).
