SIG1459( SIG-1459 | SIG 1459 )

Catalog No. M13582 CAS No. 2234902-05-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SIG1459
Note

Research use only, not for human use.
Brief Description

SIG1459 (SIG-1459) is a novel anti-acne isoprenylcysteine (IPC) small molecule that shows direct antibacterial activity and inhibits TLR2 inflammatory signaling.
Description

SIG1459 (SIG-1459) is a novel anti-acne isoprenylcysteine (IPC) small molecule that shows direct antibacterial activity and inhibits TLR2 inflammatory signaling; shows antibacterial activity against C. acnes (MIC= 8.5 uM, MBC =16.1 uM, and MBEC= 12.5 uM), inhibits TLR2 induced IL-8 release from TLR2/TLR2 (IC50= 0.086 uM), TLR2/6 (IC50= 0.209 uM) and IL-1α from TLR2/TLR2 (IC50 =0.050 uM); demonstrates in vivo anti-acne activity.
In Vitro

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In Vivo

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Synonyms

SIG-1459 | SIG 1459
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

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Indication

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CAS Number

2234902-05-5
Formula Weight

584.768
Molecular Formula

C29H50N2Na2O5S
Purity

>98% (HPLC)
Solubility

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SMILES

CC(C)CCCC(C)CCCC(C)CCCC(=CCSCC(C(=O)[O-])NC(=O)N1CCCC1C(=O)[O-])C.[Na+].[Na+]
Chemical Name

(((1R)-1-carboxy-2-(((E)-3,7,11,15-tetramethylhexadec-2-en-1-yl)thio)ethyl)carbamoyl)proline disodium salt

1. Fernández JR, et al. Exp Dermatol. 2018 Sep;27(9):993-999.

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