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CCC07-01
CAS No. 2215102-35-3
CCC07-01( CCC 07-01 | CCC 0701 )
Catalog No. M13531 CAS No. 2215102-35-3
CCC07-01 (CCC 0701) is a novel alkylating compound that is capable of disrupting expression of PD-1, PD-L1 and CTLA-4 genes with IC50 of 15, 10 and 5 nM in cell-base assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCCC07-01
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NoteResearch use only, not for human use.
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Brief DescriptionCCC07-01 (CCC 0701) is a novel alkylating compound that is capable of disrupting expression of PD-1, PD-L1 and CTLA-4 genes with IC50 of 15, 10 and 5 nM in cell-base assays.
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DescriptionCCC07-01 (CCC 0701) is a novel alkylating compound that is capable of disrupting expression of PD-1, PD-L1 and CTLA-4 genes with IC50 of 15, 10 and 5 nM in cell-base assays; significantly suppresses PD-1, PD-L1 and CTLA-4 mRNA levels in several cell lines, CCC07-01 is sufficiently lipophilic that enhaced the inhibitory effect of CD94-NKG-2A receptor expressed on subsets of NK cells γδ and CD8+ T cells.
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In Vitro——
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In Vivo——
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SynonymsCCC 07-01 | CCC 0701
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PathwayImmunology/Inflammation
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TargetPD-1/PD-L1
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RecptorPD-1/PD-L1
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Research Area——
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Indication——
Chemical Information
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CAS Number2215102-35-3
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Formula Weight1886.378
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Molecular FormulaC90H93ClN30O16
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. US Patent WO 2018056361.
2. Horiki Nagase, et al. 2018 AACR #2711: Development of a new innovative multifunctional immune checkpoint inhibitor.
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