Ketoprofen

Research use only, not for human use.

Ketoprofen is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively.

Ketoprofen is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively.(In Vitro):Ketoprofen inhibits COX in LPS-stimulated monocytes isolated from human blood, with IC50 values of 2 nM (COX-1) and 26 nM (COX-2).Ketoprofen (2.5 mg /mL, 3-24h) decreases the mRNA level of immune factors (TNFα, IL-8, SAA and COX-2) and PTGES in LPS-stimulated bovine mammary epithelial cells. (In Vivo):Ketoprofen (Oral administration, 10 mg/kg, three times a week for 10 weeks, HFD-induced obese C57BL/6 mice) decreases in relative body weight (15.41%), the iWAT mass (approximately 41%), and leptin (58.68%) and resistin (12.88%).Ketoprofen (50 mg/kg, LPS-treated dairy cows) lowers the increase of somatic cell count (SCC), serum albumin (SA), IgG and lactate dehydrogenase (LDH) activity in milk induced by LPS.

Ketoprofen inhibits COX in LPS-stimulated monocytes isolated from human blood, with IC50 values of 2 nM (COX-1) and 26 nM (COX-2).Ketoprofen (2.5 mg /mL, 3-24h) decreases the mRNA level of immune factors (TNFα, IL-8, SAA and COX-2) and PTGES in LPS-stimulated bovine mammary epithelial cells.RT-PCRCell Line:LPS (0.2 μg/mL)-stimulated bovine mammary epithelial cells Concentration:2.5 mg /mL Incubation Time:3, 6, 24 h Result:Decreased the mRNA level of TNFα, IL-8, SAA, COX-2 and PTGES.

Ketoprofen (Oral administration, 10 mg/kg, three times a week for 10 weeks, HFD-induced obese C57BL/6 mice) decreases in relative body weight (15.41%), the iWAT mass (approximately 41%), and leptin (58.68%) and resistin (12.88%).Ketoprofen (50 mg/kg, LPS-treated dairy cows) lowers the increase of somatic cell count (SCC), serum albumin (SA), IgG and lactate dehydrogenase (LDH) activity in milk induced by LPS. Animal Model:HFD-induced obese C57BL/6 mice Dosage:10 mg/kg Administration:Oral administration, three times a week for 10 weeks Result:Decreased in relative body weight, the iWAT mass, and the level of leptin and resistin.Animal Model:LPS (0.2 μg/mL)-treated dairy cows Dosage:50 mg/kg Administration:Injection (Milk samples were taken every 30 min until 6 and 9 h)Result:Lowered the increase of somatic cell count (SCC), serum albumin (SA), IgG and lactate dehydrogenase (LDH) activity in milk.

2-(3-benzoylphenyl)propionic Acid | Ketoprofen | (RS)-Ketoprofen

Chromatin/Epigenetic

COX

COX-1| COX-2| MRAP4

Inflammation/Immunology

——

22071-15-4

254.28

C16H14O3

>98% (HPLC)

Ethanol: 51 mg/mL (200.56 mM); DMSO: 51 mg/mL (200.56 mM)

CC(C1=CC=CC(C(C2=CC=CC=C2)=O)=C1)C(O)=O

2-(3-benzoylphenyl)propanoic acid

(-20℃)

With Ice Pack

≥ 2 years