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BTB06584
CAS No. 219793-45-0
BTB06584( BTB )
Catalog No. M13505 CAS No. 219793-45-0
BTB06584 is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 51 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 46 | In Stock |
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| 10MG | 64 | In Stock |
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| 25MG | 84 | In Stock |
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| 50MG | 116 | In Stock |
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| 100MG | 209 | In Stock |
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| 200MG | 324 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBTB06584
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NoteResearch use only, not for human use.
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Brief DescriptionBTB06584 is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB).
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DescriptionBTB06584 is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB). BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase.
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In VitroIn HL-1 cells, BTB06584 (100 μM) inhibits F1Fo-ATPase activity with no effect on the mitochondrial membrane potential (ΔΨm ) or O2 consumption. BTB06584 (100 μM) pretreatmet protects against ischaemic cell death in HL-1 cells prior to a period of ischaemia. ATP consumption is decreased following inhibition of respiration, and ischaemic cell death is reduced. BTB06584 efficiency is increased by IF1 overexpression and reduced by silencing the protein.
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In VivoBTB06584 (1 μM; 24 hours) treatment rescued defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants in which expression of the Atpif1a gene is lost. The concentrations of BTB06584 that restore haemoglobin biosynthesis also alter mitochondrial bioenergetics in living fish.
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SynonymsBTB
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PathwayEndocrinology/Hormones
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TargetATPase
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RecptorATPase| Acetohydroxyacid synthase
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Research AreaMetabolic Disease
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Indication——
Chemical Information
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CAS Number219793-45-0
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Formula Weight417.82
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Molecular FormulaC19H12ClNO6S
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Purity>98% (HPLC)
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SolubilityDMSO: 84 mg/mL (201.04 mM)
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SMILESO=S(C1=CC(OC(C2=CC=C(Cl)C=C2)=O)=C([N+]([O-])=O)C=C1)(C3=CC=CC=C3)=O
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Chemical Name2-nitro-5-(phenylsulfonyl)phenyl 4-chlorobenzoate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Wang D, et al. J Chem Inf Model. 2013 Feb 25;53(2):343-53.
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