PF-06873600( PF06873600 | PF 06873600 )

Catalog No. M13486 CAS No. 2185857-97-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PF-06873600
Note

Research use only, not for human use.
Brief Description

PF-06873600 (PF06873600, PF 06873600) is a potent, orally bioavailable inhibitor of cyclin-dependent kinase (CDK) with Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively.
Description

PF-06873600 (PF06873600, PF 06873600) is a potent, orally bioavailable inhibitor of cyclin-dependent kinase (CDK) with Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively; demonstrates potential antineoplastic activity, incerease apoptosis and inhibits umor cell proliferation.Breast Cancer Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

PF06873600 | PF 06873600
Pathway

Cell Cycle/DNA Damage
Target

CDK
Recptor

CDK
Research Area

Cancer
Indication

Breast Cancer

CAS Number

2185857-97-8
Formula Weight

471.524
Molecular Formula

C20H27F2N5O4S
Purity

>98% (HPLC)
Solubility

DMSO : 83.33 mg/mL 176.73 mM
SMILES

O=C1C(C(F)F)=CC2=CN=C(NC3CCN(S(=O)(C)=O)CC3)N=C2N1[C@H]4[C@](C)(O)CCC4
Chemical Name

Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-