YKL 06-061( YKL06-061 )

Catalog No. M13473 CAS No. 2172617-15-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

YKL 06-061
Note

Research use only, not for human use.
Brief Description

YKL 06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 of 6.56/1.77/20.5 nM for SIK1/2/3, respectively.
Description

YKL 06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 of 6.56/1.77/20.5 nM for SIK1/2/3, respectively; inhibits only one kinase FRK (IC50=1.1 nM), more strongly than SIKs, in a panel of 468 human kinases; dose-dependently increases MITF mRNA expression in human melanoma cells; induces significant pigmentation in Mc1r-deficient mice and normal human skin.
In Vitro

YKL 06-061 yields a dose-dependent increase in MITF mRNA expression. :RT-PC RCell Line:UACC62 human melanoma cells, and UACC257 human melanoma cells.Concentration:0-4 μM (UACC62); 0-16 μM (UACC257).Incubation Time:3 hours.Result:Yielded a dose-dependent increase in MITF mRNA expression.
In Vivo

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Synonyms

YKL06-061
Pathway

Autophagy
Target

SIK
Recptor

SIK
Research Area

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Indication

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CAS Number

2172617-15-9
Formula Weight

527.673
Molecular Formula

C30H37N7O2
Purity

>98% (HPLC)
Solubility

DMSO : 62.5 mg/mL 118.45 mM; H2O : < 0.1 mg/mL
SMILES

O=C1N(C2CCC2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4OC)=NC=C3CN1C6=C(C)C=CC=C6C
Chemical Name

Pyrimido[4,5-d]pyrimidin-2(1H)-one,1-cyclobutyl-3-(2,6-dimethylphenyl)-3,4-dihydro-7-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-

1. Mujahid N, et al. Cell Rep. 2017 Jun 13;19(11):2177-2184.

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