WY-135( WY135 )

Catalog No. M13452 CAS No. 2163060-83-9

COA

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HNMR

HPLC

MSDS

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Product Name

WY-135
Note

Research use only, not for human use.
Brief Description

WY-135 (WY135) is a novel potent inhibitor of ALK and ROS1 with IC50 of 1.2 and 0.48 nM, respectively.
Description

WY-135 (WY135) is a novel potent inhibitor of ALK and ROS1 with IC50 of 1.2 and 0.48 nM, respectively; exhibits better enzyme inhibitory activity than ceritinib, demonstrates anti-proliferative effects on Karpas299 and H2228 cells with IC50 of 28 and 164 nM respectively in MTT assay; induces cell cycle arrest at G1 phase in a dose-dependent manner and subsequently progressed into apoptosis, significantly suppressed ALK and its downstream protein expression.
In Vitro

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In Vivo

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Synonyms

WY135
Pathway

Angiogenesis
Target

ALK
Recptor

ALK
Research Area

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Indication

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CAS Number

2163060-83-9
Formula Weight

612.15
Molecular Formula

C28H34ClN9O3S
Purity

>98% (HPLC)
Solubility

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SMILES

CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4C=C(N=N4)CN5CCN(CC5)C)OC
Chemical Name

5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-((4-methylpiperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)phenyl)pyrimidine-2,4-diamine

1. Han M, et al. Chem Biol Interact. 2018 Mar 25;284:24-31. 2. Wang Y, et al. Eur J Med Chem. 2018 Jan 1;143:123-136.

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