ABBV-744( ABBV744 )

Catalog No. M13413 CAS No. 2138861-99-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

ABBV-744
Note

Research use only, not for human use.
Brief Description

ABBV-744 (ABBV744) is a potent, BDII-selective BET bromodomain inhibitor.
Description

ABBV-744 (ABBV744) is a potent, BDII-selective BET bromodomain inhibitor, ABBV-744 is a potent, selective inhibitor of the AR transcription activity; induces tumor growth inhibition in LNCaP and MDA-Pca-2b xenograft models.Prostate Cancer Phase 1 Clinical.
In Vitro

Western Blot Analysis Cell Line:LNCaP cells Concentration:90 nM Incubation Time:0~24 hours Result:Downregulated the expression of KLK2 and MYC genes.Cell Cycle Analysis Cell Line:LNCaP cells Concentration:90 nM Incubation Time:0~72 hours Result:Induced cell cycle arrest in G1 followed by senescence.
In Vivo

Animal Model:Mice Dosage:4.7 mg/kg (Pharmacokinetic Analysis)Administration:Oral gavage; 28 days Result:Caused a delay in tumor growth and displayed equivalent or better antitumor activity compared with ABBV-075.Animal Model:Sprague-Dawley rats Dosage:30 mg/kg (Pharmacokinetic Analysis) Administration:14 days Result:Produced significant antitumor activity.
Synonyms

ABBV744
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

BET bromodomain
Research Area

Cancer
Indication

Prostate Cancer

CAS Number

2138861-99-9
Formula Weight

491.563
Molecular Formula

C28H30FN3O4
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

O=C(C(N1)=CC(C(C2=CC(C(C)(O)C)=CC=C2OC3=C(C)C=C(F)C=C3C)=CN4C)=C1C4=O)NCC
Chemical Name

1H-Pyrrolo[2,3-c]pyridine-2-carboxamide, N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-hydroxy-1-methylethyl)phenyl]-6,7-dihydro-6-methyl-7-oxo-