CDK9-PROTAC( CDK9PROTAC | CDK9 PROTAC | CDK9-PROTAC )

Catalog No. M13368 CAS No. 2118356-96-8

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Datasheet

HNMR

HPLC

MSDS

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Product Name

CDK9-PROTAC
Note

Research use only, not for human use.
Brief Description

CDK9-PROTAC is a heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9.
Description

CDK9-PROTAC is a heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9; selectively degrades CDK9 while sparing other CDK family members in HCT116 cells.
In Vitro

PROTAC CDK9 Degrader-1 (Compound 3; 2.5-20 μM; 6 hours) degrades CDK9 in a dose dependent manner in HCT116 cells.Western Blot Analysis Cell Line:HCT116 cells Concentration:2.5, 5, 10, and 20μM Incubation Time:6 hours Result:Degraded CDK9 in a dose dependent manner.
In Vivo

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Synonyms

CDK9PROTAC | CDK9 PROTAC | CDK9-PROTAC
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

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Indication

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CAS Number

2118356-96-8
Formula Weight

613.671
Molecular Formula

C33H35N5O7
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 104 mg/mL 169.47 mM
SMILES

O=C(NC1=NNC(C2CCC2)=C1)CC3=CC=C(OCCCCCOC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)C=C3
Chemical Name

N-(5-cyclobutyl-1H-pyrazol-3-yl)-2-(4-((5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)pentyl)oxy)phenyl)acetamide

1. Robb CM, et al. Chem Commun (Camb). 2017 Jul 4;53(54):7577-7580.

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