CDK9-IN-4d( —— )

Catalog No. M13347 CAS No. 2105956-51-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CDK9-IN-4d
Note

Research use only, not for human use.
Brief Description

CDK9-IN-1 is a highly potent, selective CDK9 inhibitor with IC50 of 12 nM, shows good selectivity in CDKs kinase profiling assay against CDK kinases and cell proliferation inhibition.
Description

CDK9-IN-1 is a highly potent, selective CDK9 inhibitor with IC50 of 12 nM, shows good selectivity in CDKs kinase profiling assay against CDK kinases and cell proliferation inhibition; blocks the cell cycle both in G0/G1 and G2/M phase to prevent the proliferation and differentiation of cancer cells; significantly suppresses cancer with low toxicity in mice bared-breast cancer.
In Vitro

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In Vivo

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Synonyms

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Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

——
Indication

——

CAS Number

2105956-51-0
Formula Weight

569.641
Molecular Formula

C31H32FN7O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 5.2 mg/mL (9.13 mM)
SMILES

FC1=CC=C(NC(C2(CC2)C(NC3=CC=C(NC4=NC=C5C(N(C6CCCC6)C(C(N(C)C)=O)=C5)=N4)C=C3)=O)=O)C=C1
Chemical Name

N-(4-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

1. Li Y, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3231-3237.

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