PF-DcpSi
CAS No. 2092917-19-4
PF-DcpSi( —— )
Catalog No. M13280 CAS No. 2092917-19-4
A potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM; shows no significant activity for DHFR (IC50>30 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePF-DcpSi
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NoteResearch use only, not for human use.
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Brief DescriptionA potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM; shows no significant activity for DHFR (IC50>30 uM).
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DescriptionA potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM; shows no significant activity for DHFR (IC50>30 uM); has in vivo mouse CNS PK profile, shows activity in SMA mouse model by prolonging survival and improving function thereby ruling out lysosomotropism.Spinal Muscular Atrophy (SMA)Preclinical.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOther Targets
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Research AreaNeurological Disease
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IndicationSpinal Muscular Atrophy(SMA)
Chemical Information
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CAS Number2092917-19-4
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Formula Weight309.304
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Molecular FormulaC16H12FN5O
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Purity>98% (HPLC)
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Solubility——
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SMILESC1=CC(=C2C(=C1)N=C(N=C2N)N)COC3=CC(=CC(=C3)C#N)F
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Chemical Name3-((2,4-diaminoquinazolin-5-yl)methoxy)-5-fluorobenzonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Clopamide
Clopamide is a piperidine and sulfamoylbenzamide-based diuretic with thiazide-like diuretic activity.
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DPPH
DPPH is a cell-permeable, stable free radical that is commonly used to evaluate the ability of compounds to act as free radical scavengers or hydrogen donors and to measure the antioxidant activity of tissue extractsDPPH shows a strong absorption band at 517nm.
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Secretin (5 - 27), p...
Secretin (5-27, porcine) (SQ 19301) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
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