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PF-DcpSi

CAS No. 2092917-19-4

PF-DcpSi( —— )

Catalog No. M13280 CAS No. 2092917-19-4

A potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM; shows no significant activity for DHFR (IC50>30 uM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

PF-DcpSi
Note

Research use only, not for human use.
Brief Description

A potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM; shows no significant activity for DHFR (IC50>30 uM).
Description

A potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM; shows no significant activity for DHFR (IC50>30 uM); has in vivo mouse CNS PK profile, shows activity in SMA mouse model by prolonging survival and improving function thereby ruling out lysosomotropism.Spinal Muscular Atrophy (SMA)Preclinical.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Other Targets
Research Area

Neurological Disease
Indication

Spinal Muscular Atrophy(SMA)

Chemical Information

CAS Number

2092917-19-4
Formula Weight

309.304
Molecular Formula

C16H12FN5O
Purity

>98% (HPLC)
Solubility

——
SMILES

C1=CC(=C2C(=C1)N=C(N=C2N)N)COC3=CC(=CC(=C3)C#N)F
Chemical Name

3-((2,4-diaminoquinazolin-5-yl)methoxy)-5-fluorobenzonitrile

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. J Med Chem. 2017 Apr 13;60(7):3094-3108.

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