AKS1-IN-19( AKS1 inhibitor 19 )

Catalog No. M13272 CAS No. 2089638-10-6

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Product Name

AKS1-IN-19
Note

Research use only, not for human use.
Brief Description

A novel potent, selective and orally active ASK1 (MAP3K5) inhibitor with pIC50 of 8.3.
Description

A novel potent, selective and orally active ASK1 (MAP3K5) inhibitor with pIC50 of 8.3; displays good kinase selectivity with only 32 kinases having less than 30 fold selectivity in a panel of 356 kinases; inhibits phospho-JNK with pEC50 of 8.2 in cellular assays; displayed robust MAP3K pathway inhibition and reduction of infarct size in an isolated perfused heart model of cardiac injury.
In Vitro

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In Vivo

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Synonyms

AKS1 inhibitor 19
Pathway

MAPK/ERK Signaling
Target

MEK
Recptor

MEK
Research Area

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Indication

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CAS Number

2089638-10-6
Formula Weight

393.447
Molecular Formula

C21H23N5O3
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(C)OC1=CC2=C(CN(C2=O)C3=CC=CC(=N3)C4=NN=CN4C(C)CO)C=C1
Chemical Name

(R)-2-(6-(4-(1-hydroxypropan-2-yl)-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-6-isopropoxyisoindolin-1-one

1. Lanier M, et al. ACS Med Chem Lett. 2017 Feb 8;8(3):316-320.

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