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Befiradol
CAS No. 208110-64-9
Befiradol( F 13640 | NLX 112 )
Catalog No. M13242 CAS No. 208110-64-9
Befiradol (F13640, NLX 112) is a highly potent, selective 5-HT1A receptor agonist with Ki of 2.7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameBefiradol
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NoteResearch use only, not for human use.
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Brief DescriptionBefiradol (F13640, NLX 112) is a highly potent, selective 5-HT1A receptor agonist with Ki of 2.7 nM.
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DescriptionBefiradol (F13640, NLX 112) is a highly potent, selective 5-HT1A receptor agonist with Ki of 2.7 nM; exhibits agonist efficacy greater than for (±)8-OH-DPAT or buspirone; stimulates 'total G-proteins', but unlike (±)8-OH-DPAT and buspirone, more potent for Gαo activation, in rat hippocampal membranes; dose-dependently decreases extracellular 5-HT in the hippocampus and mPFC in rats, activates both 5-HT(1A) autoreceptors and postsynaptic 5-HT(1A) receptors in prefrontal cortex with a similar potency.Pain Discontinued.
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In Vitro——
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In Vivo——
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SynonymsF 13640 | NLX 112
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PathwayGPCR/G Protein
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Target5-HT Receptor
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Recptor5-HT Receptor
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Research AreaNeurological Disease
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IndicationPain
Chemical Information
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CAS Number208110-64-9
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Formula Weight393.857
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Molecular FormulaC20H22ClF2N3O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 102 mg/mL (258.98 mM)
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SMILESO=C(C1=CC=C(F)C(Cl)=C1)N2CCC(CN(C3=NC=C(C)C=C3)C)(F)CC2
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Chemical Name(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bollinger S, et al. J Med Chem. 2010 Oct 14;53(19):7167-79.
2. Lladó-Pelfort L, et al. Psychopharmacology (Berl). 2012 May;221(2):261-72.
3. Newman-Tancredi A, et al. J Pharm Pharmacol. 2017 Sep;69(9):1178-1190.
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