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Befiradol

CAS No. 208110-64-9

Befiradol( F 13640 | NLX 112 )

Catalog No. M13242 CAS No. 208110-64-9

Befiradol (F13640, NLX 112) is a highly potent, selective 5-HT1A receptor agonist with Ki of 2.7 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Befiradol
  • Note
    Research use only, not for human use.
  • Brief Description
    Befiradol (F13640, NLX 112) is a highly potent, selective 5-HT1A receptor agonist with Ki of 2.7 nM.
  • Description
    Befiradol (F13640, NLX 112) is a highly potent, selective 5-HT1A receptor agonist with Ki of 2.7 nM; exhibits agonist efficacy greater than for (±)8-OH-DPAT or buspirone; stimulates 'total G-proteins', but unlike (±)8-OH-DPAT and buspirone, more potent for Gαo activation, in rat hippocampal membranes; dose-dependently decreases extracellular 5-HT in the hippocampus and mPFC in rats, activates both 5-HT(1A) autoreceptors and postsynaptic 5-HT(1A) receptors in prefrontal cortex with a similar potency.Pain Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    F 13640 | NLX 112
  • Pathway
    GPCR/G Protein
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    208110-64-9
  • Formula Weight
    393.857
  • Molecular Formula
    C20H22ClF2N3O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 102 mg/mL (258.98 mM)
  • SMILES
    O=C(C1=CC=C(F)C(Cl)=C1)N2CCC(CN(C3=NC=C(C)C=C3)C)(F)CC2
  • Chemical Name
    (3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bollinger S, et al. J Med Chem. 2010 Oct 14;53(19):7167-79. 2. Lladó-Pelfort L, et al. Psychopharmacology (Berl). 2012 May;221(2):261-72. 3. Newman-Tancredi A, et al. J Pharm Pharmacol. 2017 Sep;69(9):1178-1190.
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