Cart
sales@molnova.com
NM107
CAS No. 20724-73-6
NM107( 2'-C-Methylcytidine | NM-107 | Valopicitabine )
Catalog No. M13224 CAS No. 20724-73-6
A nucleoside inhibitor of HCV NS5B polymerase with EC50 of 1.23 uM against HCV 1b replicon cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 32 | In Stock |
|
| 5MG | 51 | In Stock |
|
| 10MG | 69 | In Stock |
|
| 50MG | 141 | In Stock |
|
| 100MG | 176 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameNM107
-
NoteResearch use only, not for human use.
-
Brief DescriptionA nucleoside inhibitor of HCV NS5B polymerase with EC50 of 1.23 uM against HCV 1b replicon cells.
-
DescriptionA nucleoside inhibitor of HCV NS5B polymerase with EC50 of 1.23 uM against HCV 1b replicon cells; The active component of NM283.HCV Infection Phase 2 Discontinued.
-
In VitroRT-PCR Cell Line:Huh7-1 cells and cell culture-propagated HCV (HCVcc)Concentration:25 μM Incubation Time:24 hours Result:Extracellular virus titers declined in parallel with intracellular RNA levels.
-
In Vivo——
-
Synonyms2'-C-Methylcytidine | NM-107 | Valopicitabine
-
PathwayMicrobiology/Virology
-
TargetHCV
-
RecptorHCV
-
Research AreaInfection
-
IndicationHCV Infection
Chemical Information
-
CAS Number20724-73-6
-
Formula Weight257.2432
-
Molecular FormulaC10H15N3O5
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESOC[C@@H]1[C@H]([C@@]([C@H](N2C(N=C(C=C2)N)=O)O1)(C)O)O
-
Chemical NameCytidine, 2'-C-methyl-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Gardelli C, et al. J Med Chem. 2009 Sep 10;52(17):5394-407.
2. McCown MF, et al. Antimicrob Agents Chemother. 2008 May;52(5):1604-12.
molnova catalog
related products
-
VX-222
A potent and selective, nonnucleoside inhibitor of HCV NS5B polymerase inhibitor with Kd of 17 nM.
-
BMS-961955
BMS-961955 is an potent, allosteric inhibitor of HCV NS5B polymerase with EC50 of 7.9/4.3 nM for GT 1b/1a replicon respectively.
-
MK-8325
MK-8325 is a potent, selective pan-genotype HCV NS5A inhibitor with IC50 of 15, 1 and 3 pM for GT1a, GT1b and GT2a, respectively.
