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Calycosin

CAS No. 20575-57-9

Calycosin( Calycosin )

Catalog No. M13198 CAS No. 20575-57-9

Calycosin (Cyclosin) is a natural active compound with anti-oxidative and anti-inflammation activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 51 In Stock
2MG 32 In Stock
5MG 51 In Stock
10MG 92 In Stock
25MG 180 In Stock
50MG 323 In Stock
100MG 480 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Calycosin
  • Note
    Research use only, not for human use.
  • Brief Description
    Calycosin (Cyclosin) is a natural active compound with anti-oxidative and anti-inflammation activity.
  • Description
    Calycosin (Cyclosin) is a natural active compound with anti-oxidative and anti-inflammation activity.
  • In Vitro
    Cell Proliferation Assay Cell Line:MCF-7 cells Concentration:2-32 μM Incubation Time:48 h Result:Increased the MCF-7 cell number at the doses of 2-8 μM.Inhibited the proliferation of MCF-7 cells at the doses of 32 μM.
  • In Vivo
    Animal Model:Adult Male Sprague-Dawley RatsDosage:7.5-30 mg/kg Administration:i.g. daily, 3 days Result:Improved neurological deficit and infarct volum.Reduced the content of malondialdehyde (MDA), protein carbonyl and reactive oxygen species (ROS).Increased the activities of superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-Px) in a dose-dependent manner.Inhibited the expression of 4-Hydroxy-2-nonenal (4-HNE).
  • Synonyms
    Calycosin
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    TyrosiN/Ase
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    20575-57-9
  • Formula Weight
    284.26
  • Molecular Formula
    C16H12O5
  • Purity
    >98% (HPLC)
  • Solubility
    Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
  • SMILES
    O=C1C(C2=CC=C(OC)C(O)=C2)=COC3=C1C=CC(O)=C3
  • Chemical Name
    7-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)chromen-4-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhou Y, et al. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Tumour Biol. 2015 Feb 12. 2. Chen J, et al. Calycosin and genistein induce apoptosis by inactivation of HOTAIR/p-Akt signaling pathway in human breast cancer MCF-7 cells. Cell Physiol Biochem. 2015;35(2):722-8.
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