PC1244( PC 1244 )

Catalog No. M13180 CAS No. 2046185-88-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PC1244
Note

Research use only, not for human use.
Brief Description

PC1244 is a long acting fungicidal azole that targets A. fumigatus CYP51A and CYP51B.
Description

PC1244 is a long acting fungicidal azole that targets A. fumigatus CYP51A and CYP51B, inhibits ergosterol synthesis in A. fumigatus with IC50 of 8 nM; demonstrates potent antifungal activities against clinical A. fumigatus isolates with a MIC range of 0.016-0.25 ug/mL; PC1244 is also effective against a broad spectrum of pathogenic fungi (MIC= <0.0078-2 μg/ml), especially on Aspergillus terreus, Trichophyton rubrum, Candida albicans; shows fungicidal activity (MFC=2 μg/ml), 8-fold more potent than voriconazole; shows superior in vivo effects in immunocompromised mice.
In Vitro

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In Vivo

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Synonyms

PC 1244
Pathway

Microbiology/Virology
Target

Fungal
Recptor

Fungal
Research Area

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Indication

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CAS Number

2046185-88-8
Formula Weight

686.805
Molecular Formula

C38H44F2N6O4
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)-3-methylphenyl)piperazin-1-yl)-N-((1S,2S)-2-hydroxycyclohexyl)benzamide

1. Colley T, et al. Antimicrob Agents Chemother. 2018 Feb 12. pii: AAC.01941-17.

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