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AZ6197
CAS No. 2023003-94-1
AZ6197( AZ 6197 | AZ-6197 )
Catalog No. M13150 CAS No. 2023003-94-1
AZ6197 (AZ-6197) is a potent, selective, reversible inhibitor of ERK1/2 with IC50 of <0.3 nM (ERK2).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameAZ6197
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NoteResearch use only, not for human use.
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Brief DescriptionAZ6197 (AZ-6197) is a potent, selective, reversible inhibitor of ERK1/2 with IC50 of <0.3 nM (ERK2).
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DescriptionAZ6197 (AZ-6197) is a potent, selective, reversible inhibitor of ERK1/2 with IC50 of <0.3 nM (ERK2), inhibits pERK/pRSK with IC50 of 12/62 nM in A375 cells, respectively; demonstrates in vivo antitumor efficacy.
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In Vitro——
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In Vivo——
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SynonymsAZ 6197 | AZ-6197
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PathwayMAPK/ERK Signaling
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TargetERK
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RecptorERK
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Research Area——
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Indication——
Chemical Information
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CAS Number2023003-94-1
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Formula Weight442.527
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Molecular FormulaC24H26N8O
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1CN2C=C(C=C2C(=O)N1CC3=CC=CC(=N3)C)C4=NC(=NC=C4C)NC5=CC=NN5C
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Chemical Name(R)-3-Methyl-7-(5-methyl-2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-2-((6-methylpyridin-2-yl)methyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ward RA, et al. J Med Chem. 2017 Apr 27;60(8):3438-3450.
2. Decaudin D, et al. Oncotarget. 2018 Apr 24;9(31):21674-21686.
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