Z-JIB-04( NSC 693627 )

Catalog No. M13116 CAS No. 199596-24-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

Z-JIB-04
Note

Research use only, not for human use.
Brief Description

JIB-04 Z-isomer, also known as NSC 693627, is an isomer of JIB-04. JIB-04 is a Jumonji histone demethylase inhibitor.
Description

JIB-04 Z-isomer, also known as NSC 693627, is an isomer of JIB-04. JIB-04 is a Jumonji histone demethylase inhibitor. JIB-04 selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo. JIB-04 can prolong survival in a mouse model of breast cancer.
In Vitro

JIB-04 inhibits the demethylase activity of Jumonji enzymes in vitro and in cells, without affecting other α-ketoglutarate dependent hydroxylases or histone modifying enzymes .
In Vivo

——
Synonyms

NSC 693627
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

CAS Number

199596-24-2
Formula Weight

308.76
Molecular Formula

C17H13ClN4
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM
SMILES

ClC1=CN=C(N/N=C(C2=CC=CC=C2)\C3=NC=CC=C3)C=C1
Chemical Name

(Z)-5-chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine