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Loxapine
CAS No. 1977-10-2
Loxapine( Adasuve | AZ-004 | CL 62,362 | Cloxazepine | Dibenzacepin | Dibenzoazepine | HF 3170 | HF3170 )
Catalog No. M13090 CAS No. 1977-10-2
A typical antipsychotic agent that displays an extremely strong binding affinity for dopamine D4 and serotonin 5-HT2 receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 45 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameLoxapine
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NoteResearch use only, not for human use.
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Brief DescriptionA typical antipsychotic agent that displays an extremely strong binding affinity for dopamine D4 and serotonin 5-HT2 receptors.
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DescriptionA typical antipsychotic agent that displays an extremely strong binding affinity for dopamine D4 and serotonin 5-HT2 receptors.Schizophrenia Approved.
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In VitroIn the presence of Loxapine, [3H]ketanserin binds to 5-HT2 receptor in Frontal cortex of brain in human and bovine with Ki value of 6.2 nM and 6.6 nM, respectively. Loxapine has the rank order of potency for the various receptors appears to be as follows: 5-HT2≥D4>>>D1>D2 in comparing competition experiments involving the human membranes.Loxapine (0-20 μM, 24 h or 72 h) reduces IL-1β secretion by LPS-activated mixed glia cultures, reduces IL-2 secretion in mixed glia cultures, and decreases IL-1β and IL-2 secretion in LPS-induced microglia cultures.
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In Vivo——
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SynonymsAdasuve | AZ-004 | CL 62,362 | Cloxazepine | Dibenzacepin | Dibenzoazepine | HF 3170 | HF3170
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PathwayGPCR/G Protein
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Target5-HT Receptor
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Recptor5-HT Receptor
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Research AreaNeurological Disease
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IndicationSchizophrenia
Chemical Information
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CAS Number1977-10-2
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Formula Weight327.808
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Molecular FormulaC18H18ClN3O
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCN1CCN(C2=NC3=CC=CC=C3OC4=CC=C(Cl)C=C24)CC1
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Chemical NameDibenz[b,f][1,4]oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Singh AN, et al. J Psychiatry Neurosci. 1996 Jan;21(1):29-35.
2. Labuzek K, et al. Eur Neuropsychopharmacol. 2005 Jan;15(1):23-30.
3. Lee T, et al. Psychiatry Res. 1984 Aug;12(4):277-85.
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