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YKL-1-116
CAS No. 1957202-71-9
YKL-1-116( YKL-1-116 | YKL 1 116 | YKL1116 )
Catalog No. M13065 CAS No. 1957202-71-9
YKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs; synergizes with 5-FU or nutlin-3 to kill HCT116 cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1413 | Get Quote |
|
| 50MG | 2862 | Get Quote |
|
| 100MG | 3870 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameYKL-1-116
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NoteResearch use only, not for human use.
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Brief DescriptionYKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs; synergizes with 5-FU or nutlin-3 to kill HCT116 cells.
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DescriptionYKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs; synergizes with 5-FU or nutlin-3 to kill HCT116 cells, produces dose-dependent increases in PARP cleavage; is more potent than THZ1 towards both Cdk7WT and Cdk7as (analog-sensitive mutant).
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In Vitro——
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In Vivo——
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SynonymsYKL-1-116 | YKL 1 116 | YKL1116
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number1957202-71-9
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Formula Weight606.731
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Molecular FormulaC34H38N8O3
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(N(C1)C(C)(C)C2=C1C(NC3=CC=CC(NC(C4=CC=C(NC(C=C)=O)C=C4)=O)=C3)=NN2)N[C@@H](C5=CC=CC=C5)CN(C)C
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Chemical Name(S)-3-((3-(4-acrylamidobenzamido)phenyl)amino)-N-(2-(dimethylamino)-1-phenylethyl)-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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SEL120-34A hydrochlo...
SEL120-34A is an ATP-competitive, selective, orally active CDK8 inhibitor that inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50 of 4.4 nM and 10.4 nM, respectively.
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Trilaciclib hydrochl...
Trilaciclib hydrochloride is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6).Incubation with Trilaciclib hydrochloride (G1T28) for 24 hours can induce a strong G1 cell cycle arrest (time=0). Cells have re-entered the cell cycle and demonstrate cell-cycle kinetics similar to untreated control cells By 16 hours after Trilaciclib hydrochloride washout.
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iCDK9
iCDK9 (i-CDK9) is a potent, highly selective CDK9 inhibitor (IC50<0.4 nM, CDK9-CycT1 kinase), exhibits >600-fold selectivity toward CDK1-CycB, CDK2-CycA, CDK4-CycD1, CDK7-CycH-MAT1 and CDK8-CycC.
