MTX-211( MTX 211 )

Catalog No. M13055 CAS No. 1952236-05-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MTX-211
Note

Research use only, not for human use.
Brief Description

A first-in-class, highly selective, dual inhibitor of PI3K and EGFR kinases.
Description

A first-in-class, highly selective, dual inhibitor of PI3K and EGFR kinases with demonstrated in vivo anticancer activity against multiple KRAS mutant colorectal tumors; shows limited off-target toxicity and a broad therapeutic window.
In Vitro

MTX-211 (MOL211) has inhibitory activity for both EGFR and PI3K Alpha with IC50 values of ＜100 nM.
In Vivo

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Synonyms

MTX 211
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

EGFR|PI3K
Research Area

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Indication

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CAS Number

1952236-05-3
Formula Weight

478.323
Molecular Formula

C20H14Cl2FN5O2S
Purity

>98% (HPLC)
Solubility

DMSO: ≥100 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

CS(=O)(NC1=CC(C2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2)=CN=C1Cl)=O
Chemical Name

Methanesulfonamide, N-[2-chloro-5-[4-[(3-chloro-4-fluorophenyl)amino]-6-quinazolinyl]-3-pyridinyl]-