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Aminoguanidine hydrochloride
CAS No. 1937-19-5
Aminoguanidine hydrochloride( Aminoguanidinium chloride | GER 11 | Pimagedine )
Catalog No. M13039 CAS No. 1937-19-5
Aminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
|
| 50MG | 33 | In Stock |
|
| 100MG | 47 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 75 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAminoguanidine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionAminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor.
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DescriptionAminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor, reduces levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone, is an investigational drug for the treatment of diabetic nephropathy.
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In VitroApoptosis Analysis Cell Line:A549Concentration:100-1000 μM Incubation Time:24 h Result:Showed protective effect on DOX-induced DNA damage and decreased DOX-induced apoptosis.Cell Proliferation Assay Cell Line:AR42J Concentration:100 μM Incubation Time:24-96 h Result:Showed a significant increase in cell proliferation after incubation for 48 h.
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In VivoAnimal Model:Male Swiss albino miceDosage:50 mg/kg Administration:Intraperitoneally 30 min before the administration of CCl4 Result:Inhibited the serum AST level and protected hepatotoxin-induced lipid peroxidation.Animal Model:Adult male Wistar ratsDosage:200 mg/kg Administration:Intraperitoneally 1 hour before the administration of CP and killed 16 hours after CP injection.Result:Attenuated CP-induced MDA elevation and prevented CP-induced protein oxidation.Restored the GSH levels and attenuated CP-induced increase in MPO activity.
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SynonymsAminoguanidinium chloride | GER 11 | Pimagedine
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PathwayImmunology/Inflammation
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TargetNOS
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RecptoriNOS
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Research AreaEndocrinology
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Indication——
Chemical Information
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CAS Number1937-19-5
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Formula Weight110.55
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Molecular FormulaCH6N4·HCl
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM
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SMILESCl.NN=C(N)N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Imming P, et al. Nat Rev Drug Discov. 2006 Oct; 5(10):821-34.
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