BRL-15572 dihydrochloride( BRL15572 | BRL 15572 )

Catalog No. M13033 CAS No. 193611-72-2

BRL-15572 is a potent, selective h5-HT1D receptor antagonist.

Purity : >98% (HPLC)

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Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	29	In Stock
10MG	38	In Stock
25MG	62	In Stock
50MG	93	In Stock
100MG	138	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

BRL-15572 dihydrochloride
Note

Research use only, not for human use.
Brief Description

BRL-15572 is a potent, selective h5-HT1D receptor antagonist.
Description

BRL-15572 is a potent, selective h5-HT1D receptor antagonist with pKi of 7.9, dispalys 60-fold selectivity over h5-HT1B; shows binding affinities for 5-HT1A, 5-HT1B, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6 and 5-HT7 with pKi of 7.7, 6.1, 5.2, 6.0, 6.6, 7.4, 6.2, 5.9 and 6.3, respectively.
In Vitro

BRL-15572 has 60-fold higher affinity for h5-HT1D (pKi=7.9) than 5-HT1B receptors on human receptors expressed in CHO cells.BRL-15572 (0.1 nM-10 μM) stimulates [35S]GTPγS binding in CHO cell membranes expressing h5-HT1B and h5-HT1D receptors.
In Vivo

BRL-15572 prevents (-)-epicatechin-induced antinociception in the formalin test.BRL-15572 (0.3-100.0 mg/kg; i.p.) is inactive and BRL-15572 (0.1-10 mg/kg; i.p.) has no effect on body temperature the guinea pig.
Synonyms

BRL15572 | BRL 15572
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

5-HT1A| 5-HT1D| 5-HT2A| 5-HT2B| 5-HT7
Research Area

Neurological Disease
Indication

——

Chemical Information

CAS Number

193611-72-2
Formula Weight

479.8696
Molecular Formula

C25H29Cl3N2O
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

C1CN(CCN1CC(C(C2=CC=CC=C2)C3=CC=CC=C3)O)C4=CC(=CC=C4)Cl.Cl.Cl
Chemical Name

1-Piperazineethanol, 4-(3-chlorophenyl)-.alpha.-(diphenylmethyl)-, hydrochloride (1:2)

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Price GW, et al. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20. 2. Schlicker E, et al. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):321-7. 3. De Vries P, et al. Eur J Pharmacol. 1998 Nov 27;362(1):69-72. 4. Marcoli M, et al. Br J Pharmacol. 1999 Feb;126(3):607-12.

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