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ZM 323881 hydrochloride
CAS No. 193000-39-4
ZM 323881 hydrochloride( —— )
Catalog No. M13023 CAS No. 193000-39-4
ZZZM 323881 hydrochloride is a potent and selective VEGFR2 inhibitor with IC50 of <2 nM, almost no activity on VEGFR1, PDGFRβ, FGFR1, EGFR and ErbB2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 63 | In Stock |
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| 5MG | 61 | In Stock |
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| 10MG | 98 | In Stock |
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| 25MG | 237 | In Stock |
|
| 50MG | 380 | In Stock |
|
| 100MG | 569 | In Stock |
|
| 200MG | 806 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameZM 323881 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionZZZM 323881 hydrochloride is a potent and selective VEGFR2 inhibitor with IC50 of <2 nM, almost no activity on VEGFR1, PDGFRβ, FGFR1, EGFR and ErbB2.
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DescriptionZZZM 323881 hydrochloride is a potent and selective VEGFR2 inhibitor with IC50 of <2 nM, almost no activity on VEGFR1, PDGFRβ, FGFR1, EGFR and ErbB2.
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In VitroZM323881 is an anilinoquinazoline that potently inhibits VEGFR2 (KDR) tyrosine kinase activity anddemonstrates excellent selectivity versus other receptor tyrosine kinases, including PDGFRβ, FGFR1, EGFR and erbB2 (IC50>50 μM). ZM323881 inhibits VEGF-A-induced endothelial cell proliferation(IC50=8 nM) and VEGFR2 tyrosine phosphorylation. ZM323881 inhibits activation of VEGFR-2, but not of VEGFR-1, epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), or hepatocyte growth factor (HGF) receptor. In HAECs, ZM323881 completely inhibits VEGF-induced ERK phosphorylation at 1 μM.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR| FGFR1| PDGFRβ| VEGFR1| VEGFR2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number193000-39-4
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Formula Weight411.86
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Molecular FormulaC22H19ClFN3O2
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mg/mL (24.28 mM)
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SMILESCl.CC1=CC(F)=C(NC2=NC=NC3=C2C=CC(OCC2=CC=CC=C2)=C3)C=C1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Whittles CE, et al. Microcirculation, 2002, 9(6), 513-522.
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