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Lopinavir
CAS No. 192725-17-0
Lopinavir( A-157378.0 | ABT-378 )
Catalog No. M13020 CAS No. 192725-17-0
Lopinavir (also known as ABT-378) is a highly potent inhibitor of human immunodeficiency virus (HIV) protease that potently inhibits wild-type and mutant HIV protease.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 37 | In Stock |
|
| 100MG | 59 | In Stock |
|
| 200MG | 87 | In Stock |
|
| 500MG | 178 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLopinavir
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NoteResearch use only, not for human use.
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Brief DescriptionLopinavir (also known as ABT-378) is a highly potent inhibitor of human immunodeficiency virus (HIV) protease that potently inhibits wild-type and mutant HIV protease.
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DescriptionLopinavir (also known as ABT-378) is a highly potent inhibitor of human immunodeficiency virus (HIV) protease that potently inhibits wild-type and mutant HIV protease.(In Vitro):HIV-1 protease is an essential enzyme for production of mature, infective virus.Lopinavir potently inhibits wild-type and mutant HIV protease (Ki= 1.3 to 3.6 pM), blocks the replication of laboratory and clinical strains of HIV type 1 (EC50=0.006 to 0.017 μM), and maintains high potency against mutant HIV selected by Ritonavir in vivo (EC50=≤0.06 μM).(In Vivo):Coadministration with low-dose Ritonavir significantly improves the pharmacokinetic properties and hence the activity of Lopinavir against HIV-1 protease.
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In Vitro——
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In Vivo——
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SynonymsA-157378.0 | ABT-378
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV protease
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number192725-17-0
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Formula Weight628.8
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Molecular FormulaC37H48N4O5
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Purity>98% (HPLC)
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SolubilityEthanol: 126 mg/mL (200.38 mM); DMSO: 126 mg/mL (200.38 mM)
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SMILESCC1=C(C(=CC=C1)C)OCC(=O)N[C@@H](CC2=CC=CC=C2)[C@H](C[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)N4CCCNC4=O)O
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Chemical Name(2S)-N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Feruloyltyramine
NTF is likely to inhibit COX enzymes, thereby suppressing P-selectin expression on platelets, is a platelet aggregation inhibitor.
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Fostemsavir Tris
Fostemsavir Tris is the prodrug of BMS-626529,is a oral, safe and effective?inhibitor of HIV-1 attachment.?It inhibits human immunodeficiency virus type 1 (HIV-1) infection by binding to gp120 and interfering with the attachment of virus to CD4+ T-cells.
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Helichrysetin
Helichrysetin has mild anti-HIV-1 PR activity. Helichrysetin has great potentials for development as an anticancer agent, it has cytotoxic effect on four selected cancer cell lines, A549, MCF-7, Ca Ski, and HT-29.Searching for anti-HIV-1 protease (PR) inhibitors of Thai medicinal plants led to the isolation of a new cyclohexenyl chalcone named panduratin C and chalcone derivatives (2-6) from the methanol extract of Boesenbergia pandurata rhizomes.
