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Traxoprodil mesylate
CAS No. 188591-67-5
Traxoprodil mesylate( CP-101606 mesylate )
Catalog No. M12949 CAS No. 188591-67-5
A potent, selective N-methyl-D-aspartate (NMDA) antagonist with selectivity for the NR2B subunit; potently protects cultured hippocampal neurons from glutamate toxicity (IC50=10 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameTraxoprodil mesylate
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective N-methyl-D-aspartate (NMDA) antagonist with selectivity for the NR2B subunit; potently protects cultured hippocampal neurons from glutamate toxicity (IC50=10 nM).
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DescriptionA potent, selective N-methyl-D-aspartate (NMDA) antagonist with selectivity for the NR2B subunit; potently protects cultured hippocampal neurons from glutamate toxicity (IC50=10 nM), dramatically reduces both the open dwell-time and frequency of channel opening of NR1/NR2B-containing receptors, but only modestly inhibits NR1/NR2A and NR1/NR2C channel activity; exhibits neuroprotective, analgesic, and anti-Parkinsonian effects in animal studies.Depression Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsCP-101606 mesylate
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PathwayMembrane Transporter/Ion Channel
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TargetiGluR
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RecptoriGluR
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Research AreaNeurological Disease
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IndicationDepression
Chemical Information
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CAS Number188591-67-5
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Formula Weight423.524
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Molecular FormulaC21H29NO6S
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)(C3=CC=CC=C3)O.CS(=O)(=O)O
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Chemical Name(1S,2S)-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol mesylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chenard BL,?et al. J Med Chem. 1995 Aug 4;38(16):3138-45.
2. Taniguchi K, et al. Br J Pharmacol. 1997 Nov;122(5):809-12.
3. Brimecombe JC, et al. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):11019-24.
4. Guscott MR, et al. Eur J Pharmacol. 2003 Aug 29;476(3):193-9.
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