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AMG-176
CAS No. 1883727-34-1
AMG-176( AMG 176 | AMG176 )
Catalog No. M12935 CAS No. 1883727-34-1
AMG-176 (AMG176) is a novel, potent and selective Mcl-1 inhibitor that binds with high affinity and selectivity to the BH3-binding groove of Mcl-1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 100MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameAMG-176
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NoteResearch use only, not for human use.
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Brief DescriptionAMG-176 (AMG176) is a novel, potent and selective Mcl-1 inhibitor that binds with high affinity and selectivity to the BH3-binding groove of Mcl-1.
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DescriptionAMG-176 (AMG176) is a novel, potent and selective Mcl-1 inhibitor that binds with high affinity and selectivity to the BH3-binding groove of Mcl-1; disrupts the interaction between Mcl-1 and Bak, leading to downstream activation of the intrinsic apoptosis pathway in a cell based split-luciferase complementation assay; shows robust anti-tumor activity in Mcl-1 dependent cancer models; orally bioavailable.
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In Vitro——
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In Vivo——
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SynonymsAMG 176 | AMG176
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBcl-2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1883727-34-1
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Formula Weight613.21
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Molecular FormulaC33H41ClN2O5S
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Purity>98% (HPLC)
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SolubilityDMSO : 62.5 mg/mL 101.92 mM
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SMILESO=C(N1)C2=CC(N(C[C@H]3[C@@H](CC3)[C@@H](OC)/C=C/C[C@H](C)[C@@H](C)S1(=O)=O)C4)=C(C=C2)OC[C@@]54CCCC6=CC(Cl)=CC=C65
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Chemical NameSpiro[5,7-etheno-1H,11H-cyclobut[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-2(3H),1'(2'H)-naphthalen]-8(9H)-one, 6'-chloro-3',4',12,13,16,16a,17,18,18a,19-decahydro-16-methoxy-11,12-dimethyl-,10,10-dioxide, (1'S,11R,12S,14E,16S,16aR,18aR)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Gossypol
Gossypol (BL-193) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes.
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Paederosidic acid
Paederosidic acid has significant anti-tumor anticonvulsant and sedative effects. Paederosidic acid increases brain gamma-aminobutyric acid and decreases glutamic acid in the brain and it up-regulates expressions of GAD 65 may be a promising future therapeutic agent for treatment of epilepsy.
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trans-Ferulic acid
Trans-Ferulic acid causes the phosphorylation of β-catenin resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin.trans-Ferulic acid exert both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299.
