Cart
sales@molnova.com
MSC-2530818
CAS No. 1883423-59-3
MSC-2530818( MSC 2530818 | MSC2530818 )
Catalog No. M12925 CAS No. 1883423-59-3
MSC-2530818 (MSC 2530818, MSC2530818) is a potent, selective, and orally bioavailable CDK8 inhibitor with IC50 of 2.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 154 | In Stock |
|
| 5MG | 140 | In Stock |
|
| 10MG | 227 | In Stock |
|
| 25MG | 487 | In Stock |
|
| 50MG | 714 | In Stock |
|
| 100MG | 995 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameMSC-2530818
-
NoteResearch use only, not for human use.
-
Brief DescriptionMSC-2530818 (MSC 2530818, MSC2530818) is a potent, selective, and orally bioavailable CDK8 inhibitor with IC50 of 2.6 nM.
-
DescriptionMSC-2530818 (MSC 2530818, MSC2530818) is a potent, selective, and orally bioavailable CDK8 inhibitor with IC50 of 2.6 nM; binds to CDK8 and CDK19 with similar affinity (4 nM), and displays good selectivity profile in a 264 kinase panel with exception of GSK3α (IC50=691 nM); potently inhibits of phospho-STAT1 S727 in SW620 cells (IC50=8 nM), shows potent inhibition of WNT-dependent transcription in human cancer cell lines; demonstrates tumor growth inhibition in an APC mutant SW620 human colorectal carcinoma xenograft model.
-
In Vitro——
-
In Vivo——
-
SynonymsMSC 2530818 | MSC2530818
-
PathwayAngiogenesis
-
TargetCDK
-
RecptorCDK
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number1883423-59-3
-
Formula Weight340.811
-
Molecular FormulaC18H17ClN4O
-
Purity>98% (HPLC)
-
SolubilityDMSO : ≥ 125 mg/mL 366.77 mM
-
SMILESO=C(N1[C@H](C2=CC=C(Cl)C=C2)CCC1)C3=CN=C(NN=C4C)C4=C3
-
Chemical Name[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Czodrowski P, et al. J Med Chem. 2016 Oct 27;59(20):9337-9349.
molnova catalog
related products
-
Amsilarotene
Amsilarotene inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest.
-
Ryuvidine
Ryuvidine is a potent, selective CDK4 inhibitor with IC50 of 6.0 uM, displays >30-fold selectivity over CDK2 (IC50>100 uM).
-
LY-3177833
A potent and selective CDC7 inhibitor with IC50 of 3.3 nM.
