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Rimeporide
CAS No. 187870-78-6
Rimeporide( EMD87580 | EMD-87580 )
Catalog No. M12914 CAS No. 187870-78-6
Rimeporide (EMD87580) is a potent, selective sodium hydrogen exchanger NHE1 inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 110 | In Stock |
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| 2MG | 56 | In Stock |
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| 5MG | 92 | In Stock |
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| 10MG | 169 | In Stock |
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| 25MG | 377 | In Stock |
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| 50MG | 541 | In Stock |
|
| 100MG | 771 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRimeporide
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NoteResearch use only, not for human use.
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Brief DescriptionRimeporide (EMD87580) is a potent, selective sodium hydrogen exchanger NHE1 inhibitor.
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DescriptionRimeporide (EMD87580) is a potent, selective sodium hydrogen exchanger NHE1 inhibitor, show promise as potential therapeutic agents for the treatment of heart failure.Heart Failure Discontinued(In Vitro):Blocking NHE-1 activity has been shown to decrease intracellular Na+ and Ca2+ overload and pH and Rimeporide (EMD-87580) represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide (EMD-87580) is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent.
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In VitroBlocking NHE-1 activity has been shown to decrease intracellular Na+ and Ca2+ overload and pH and Rimeporide (EMD-87580) represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide (EMD-87580) is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent.
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In Vivo——
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SynonymsEMD87580 | EMD-87580
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PathwayMembrane Transporter/Ion Channel
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TargetSodium Channel
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RecptorNHE-1
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Research Area——
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Indication——
Chemical Information
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CAS Number187870-78-6
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Formula Weight333.377
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Molecular FormulaC11H15N3O5S2
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Purity>98% (HPLC)
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SolubilityDMSO: 15 mg/mL,50 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESCC1=CC(=C(C=C1C(=O)NC(=N)N)S(=O)(=O)C)S(=O)(=O)C
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Chemical NameN-(diaminomethylidene)-2-methyl-4,5-bis(methylsulfonyl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cox CS Jr, et al. Chest. 2003 Jan;123(1):187-94.
2. Corvera JS, et al .Ann Thorac Surg. 2003 Nov;76(5):1614-22.
3. Chen L, et al. Am J Physiol Heart Circ Physiol. 2004 Jan;286(1):H381-7.
4. Javadov S, et al. J Mol Cell Cardiol. 2005 Jan;38(1):135-43.
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Rimeporide hydrochlo...
Rimeporide (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.
